A prospective study of anti-chromatin and anti-C1q autoantibodies in patients with proliferative lupus nephritis treated with cyclophosphamide pulses or azathioprine/methylprednisolone.

@article{Grootscholten2007APS,
  title={A prospective study of anti-chromatin and anti-C1q autoantibodies in patients with proliferative lupus nephritis treated with cyclophosphamide pulses or azathioprine/methylprednisolone.},
  author={Cecile Grootscholten and J{\"u}rgen W C Dieker and Fabian D. G. McGrath and Anja Roos and R. W. Derksen and Johan van der Vlag and Mohamed R. Daha and J. H. M. Berden},
  journal={Annals of the rheumatic diseases},
  year={2007},
  volume={66 5},
  pages={693-6}
}
OBJECTIVE To study the prevalence and course of anti-chromatin (anti-nucleosome, anti-double-stranded (ds) DNA and anti-histone) and anti-C1q autoantibodies in patients with proliferative lupus nephritis (LN), treated in a randomised controlled trial with either cyclophosphamide or azathioprine plus methylprednisolone. METHODS Autoantibody levels were measured and analysed in 52 patients with proliferative LN, during their first year of treatment. Levels in both treatment arms were compared… CONTINUE READING

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