A prospective study of N-acetyltransferase genotype, red meat intake, and risk of colorectal cancer.

@article{Chen1998APS,
  title={A prospective study of N-acetyltransferase genotype, red meat intake, and risk of colorectal cancer.},
  author={Jiu Chiuan Chen and Mier J Stampfer and Hilary Hough and Montserrat Garc{\'i}a-Closas and Walter C Willett and Charles H Hennekens and Karl T. Kelsey and David J. Hunter},
  journal={Cancer research},
  year={1998},
  volume={58 15},
  pages={
          3307-11
        }
}
Carcinogenic heterocyclic amines are activated by N-acetyltransferase (NAT) enzymes, encoded by NAT1 and NAT2, to genotoxic compounds that can form DNA adducts in the colon epithelium. We have examined the relation of polymorphisms in the genes coding for both enzymes to risk of colorectal cancer and the gene-environment interaction with red meat intake among participants in the prospective Physicians' Health Study. Baseline blood samples from 212 men subsequently diagnosed with colorectal… CONTINUE READING
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