A prospective study of 2 major age-related macular degeneration susceptibility alleles and interactions with modifiable risk factors.

@article{Schaumberg2007APS,
  title={A prospective study of 2 major age-related macular degeneration susceptibility alleles and interactions with modifiable risk factors.},
  author={Debra A. Schaumberg and Susan E. Hankinson and Qun Guo and Eric B. Rimm and David J. Hunter},
  journal={Archives of ophthalmology},
  year={2007},
  volume={125 1},
  pages={55-62}
}
OBJECTIVES To delineate the magnitude of susceptibility to age-related macular degeneration (AMD) due to common variants in the gene for complement factor H (CFH) and the predicted gene LOC387715 and to determine whether these variants interact with modifiable risk factors. METHODS We compared cases who developed AMD (n = 457) with 1071 age- and sex-matched control subjects in a prospective nested case-control study within the Nurses' Health Study and the Health Professionals Follow-up Study… CONTINUE READING