A prospective randomized study to determine the optimal dose of intravenous vitamin K in reversal of over-warfarinization.

@article{Hung2000APR,
  title={A prospective randomized study to determine the optimal dose of intravenous vitamin K in reversal of over-warfarinization.},
  author={Alida Hung and Sudir Singh and R Campbell Tait},
  journal={British journal of haematology},
  year={2000},
  volume={109 3},
  pages={
          537-9
        }
}
The optimal management of asymptomatic overanticoagulated patients remains unknown. We measured international normalized ratio (INR), activated partial thromboplastin time (APTT) and prothrombin fragment 1 + 2 (F1 + 2) over 7 d in 24 asymptomatic or mildly haemorrhagic patients on warfarin with prolonged INR of > 7.0 who were randomized to receive 0.5 mg, 1 mg or 2 mg intravenous vitamin K. Of six severely overanticoagulated patients (INR > 9.5 with APTT ratio > 2), five failed to achieve an… CONTINUE READING
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