A prospective randomized controlled trial comparing simethicone, N-acetylcysteine, sodium bicarbonate and peppermint for visualization in upper gastrointestinal endoscopy

  title={A prospective randomized controlled trial comparing simethicone, N-acetylcysteine, sodium bicarbonate and peppermint for visualization in upper gastrointestinal endoscopy},
  author={Prasit Mahawongkajit and Amonpon Kanlerd},
  journal={Surgical Endoscopy},
Objectives Early cancer detection is crucial in improving the patients’ quality of life and upper gastrointestinal endoscopy (EGD) plays a key role in this detection. Many clearing mechanisms may be applied to create good endoscopic visualizations for the upper gastrointestinal tract using mucolytic agents, antifoaming agents, proteolytic enzymes and neutralizers. The aim of this study is to compare the effects of simethicone, N -acetylcysteine (NAC), sodium bicarbonate and peppermint as pre… 

Pre-Endoscopy Drink of Simethicone and N-Acetylcysteine Significantly Improves Visualization in Upper Gastrointestinal Endoscopy

A pre-endoscopy drink of NAC with simethicone can significantly improve mucosal visibility during UGIE and is safe, cheap, easily available and maybe considered for routine utilization for ensuring optimal endoscopic outcomes.

[Why is it important to detect atrophic gastritis and gastric intestinal metaplasia? What is the proper way to do it?]

  • M. SaremR. Corti
  • Medicine
    Revista de gastroenterologia del Peru : organo oficial de la Sociedad de Gastroenterologia del Peru
  • 2020
The aim of this review is to provide an update regarding the problem, diagnosis, and management of PCCs with an emphasis on the role of appropriate endoscopic detection.



A randomized controlled trial of pre-procedure simethicone and N-acetylcysteine to improve mucosal visibility during gastroscopy – NICEVIS

A pre-procedure drink containing simethicone and NAC significantly improves mucosal visibility during gastroscopy and reduces the need for flushes during the procedure.

Premedication with N-acetylcysteine and simethicone improves mucosal visualization during gastroscopy: a randomized, controlled, endoscopist-blinded study

Whether the use of a premedication solution containing the mucolytic agent N-acetylcysteine and the surfactant simethicone improves mucosal visualization within a UK diagnostic gastroscopy service is determined.

Premedication with pronase or N-acetylcysteine improves visibility during gastroendoscopy: an endoscopist-blinded, prospective, randomized study.

Premedication with pronase or NAC at 20 min before UGI endoscopy improves the mucosal visibility of the stomach and neither pronase nor NAC produces any obvious interference with the CLO test for the identification of H pylori infection.

Pre-medication to improve esophagogastroduodenoscopic visibility: a meta-analysis and systemic review.

There is improved visibility with pre-medication using Simethicone before esophagogastroduodenoscopy, and administration of Pronase or N-acetyl-Lcysteine may be of little use in improving visibility.

Peppermint oil reduces gastric spasm during upper endoscopy: a randomized, double-blind, double-dummy controlled trial.

Peppermint oil solution administered intraluminally can be used as an antispasmodic agent with superior efficacy and fewer side effects than hyoscine-N-butylbromide administered by intramuscular injection during upper endoscopy.

Determination of the Optimal Time for Premedication With Pronase, Dimethylpolysiloxane, and Sodium Bicarbonate for Upper Gastrointestinal Endoscopy

Administration of pronase, dimethylpolysiloxane, and sodium bicarbonate within 30 minutes before UGI endoscopy significantly improved endoscopic visualization, however, the optimal time to achieve the best visibility was between 10 to 30 minutesbefore UGIendoscopy.

Peppermint Oil Solution Is Useful as an Antispasmodic Drug for Esophagogastroduodenoscopy, Especially for Elderly Patients

Peppermint oil was useful as an antispasmodic during EGD, especially for elderly patients, and there was no significant difference in the antispAsmodic score between Group PO and Group HB.

Effect of premedication on lesion detection rate and visualization of the mucosa during upper gastrointestinal endoscopy: a multicenter large sample randomized controlled double-blind study

Premedication with pronase and simethicone may not increase lesion detection rates but could significantly increase the upper gastrointestinal mucosal visibility.

A defoaming agent should be used with pronase premedication to improve visibility in upper gastrointestinal endoscopy.

Premedication as in group E provided the clearest endoscopic visibility and H. pylori identification using the CLO test, and without the application of DMPS, pronase alone cannot improve endoscopy.