A prospective randomized controlled trial comparing simethicone, N-acetylcysteine, sodium bicarbonate and peppermint for visualization in upper gastrointestinal endoscopy

@article{Mahawongkajit2020APR,
  title={A prospective randomized controlled trial comparing simethicone, N-acetylcysteine, sodium bicarbonate and peppermint for visualization in upper gastrointestinal endoscopy},
  author={Prasit Mahawongkajit and Amonpon Kanlerd},
  journal={Surgical Endoscopy},
  year={2020},
  volume={35},
  pages={303-308}
}
Objectives Early cancer detection is crucial in improving the patients’ quality of life and upper gastrointestinal endoscopy (EGD) plays a key role in this detection. Many clearing mechanisms may be applied to create good endoscopic visualizations for the upper gastrointestinal tract using mucolytic agents, antifoaming agents, proteolytic enzymes and neutralizers. The aim of this study is to compare the effects of simethicone, N -acetylcysteine (NAC), sodium bicarbonate and peppermint as pre… 

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A pre-endoscopy drink of NAC with simethicone can significantly improve mucosal visibility during UGIE and is safe, cheap, easily available and maybe considered for routine utilization for ensuring optimal endoscopic outcomes.

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References

SHOWING 1-10 OF 37 REFERENCES

Premedication with simethicone and N-acetylcysteine in improving visibility during upper endoscopy: a double-blind randomized trial.

Premedication with simethicone resulted in better mucosal visibility and might improve diagnostic yield, and should be considered for standard practice.

A randomized controlled trial of pre-procedure simethicone and N-acetylcysteine to improve mucosal visibility during gastroscopy – NICEVIS

A pre-procedure drink containing simethicone and NAC significantly improves mucosal visibility during gastroscopy and reduces the need for flushes during the procedure.

Premedication with N-acetylcysteine and simethicone improves mucosal visualization during gastroscopy: a randomized, controlled, endoscopist-blinded study

Whether the use of a premedication solution containing the mucolytic agent N-acetylcysteine and the surfactant simethicone improves mucosal visualization within a UK diagnostic gastroscopy service is determined.

Systematic review and meta-analysis of randomized controlled trials of Simethicone for gastrointestinal endoscopic visibility

Supplemental use of Simethicone before endoscopy improves the small bowel visualization quality (SBVQ), especially for patients who received no purgative, but does not affect the CE completion rate.

Premedication with pronase or N-acetylcysteine improves visibility during gastroendoscopy: an endoscopist-blinded, prospective, randomized study.

Premedication with pronase or NAC at 20 min before UGI endoscopy improves the mucosal visibility of the stomach and neither pronase nor NAC produces any obvious interference with the CLO test for the identification of H pylori infection.

Peppermint oil reduces gastric spasm during upper endoscopy: a randomized, double-blind, double-dummy controlled trial.

Peppermint oil solution administered intraluminally can be used as an antispasmodic agent with superior efficacy and fewer side effects than hyoscine-N-butylbromide administered by intramuscular injection during upper endoscopy.

Determination of the Optimal Time for Premedication With Pronase, Dimethylpolysiloxane, and Sodium Bicarbonate for Upper Gastrointestinal Endoscopy

Administration of pronase, dimethylpolysiloxane, and sodium bicarbonate within 30 minutes before UGI endoscopy significantly improved endoscopic visualization, however, the optimal time to achieve the best visibility was between 10 to 30 minutesbefore UGIendoscopy.

Peppermint Oil Solution Is Useful as an Antispasmodic Drug for Esophagogastroduodenoscopy, Especially for Elderly Patients

Peppermint oil was useful as an antispasmodic during EGD, especially for elderly patients, and there was no significant difference in the antispAsmodic score between Group PO and Group HB.

Effect of premedication on lesion detection rate and visualization of the mucosa during upper gastrointestinal endoscopy: a multicenter large sample randomized controlled double-blind study

Premedication with pronase and simethicone may not increase lesion detection rates but could significantly increase the upper gastrointestinal mucosal visibility.