A prospective randomized comparison of continuous infusion fluorouracil with a conventional bolus schedule in metastatic colorectal carcinoma: a Mid-Atlantic Oncology Program Study.

@article{Lokich1989APR,
  title={A prospective randomized comparison of continuous infusion fluorouracil with a conventional bolus schedule in metastatic colorectal carcinoma: a Mid-Atlantic Oncology Program Study.},
  author={Jacob J. Lokich and James D. Ahlgren and John J. Gullo and Jennifer A Philips and John G. Fryer},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={1989},
  volume={7 4},
  pages={425-32}
}
One hundred seventy-nine patients with advanced measurable colorectal cancer not previously treated with chemotherapy were entered into a prospective randomized clinical trial by the Mid-Atlantic Oncology Program (MAOP) to compare two schedules of delivery for single-agent fluorouracil (5-FU). The "standard" treatment was a schedule commonly employed in clinical practice, namely, a daily bolus dose administered intravenously (IV) for five consecutive days and repeated at 5-week intervals. The… CONTINUE READING

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