A prospective observational post-marketing study of natalizumab-treated multiple sclerosis patients: clinical, radiological and biological features and adverse events. The BIONAT cohort.

@article{Outteryck2014APO,
  title={A prospective observational post-marketing study of natalizumab-treated multiple sclerosis patients: clinical, radiological and biological features and adverse events. The BIONAT cohort.},
  author={Olivier Outteryck and J. C. Ongagna and Bruno Brochet and Lucien Rumbach and Christine Lebrun-Fr{\'e}nay and Marc Debouverie and H{\'e}l{\`e}ne Z{\'e}phir and J C Ouallet and Eric H. Berger and Mitchell H. Cohen and Sophie Pittion and David-Axel Laplaud and Sandrine Wiertlewski and Philippe Cabre and Jean Pelletier and A Palomeque Rico and Gilles Defer and Nathalie Derache and William Camu and Eric Thouvenot and Thibault Moreau and Agn{\`e}s Fromont and Ayman Tourbah and Pierre Labauge and Giovanni Castelnovo and Pierre Clavelou and Olivier Casez and Patrick Hautecoeur and Caroline Papeix and Catherine Lubetzki and Bertrand Fontaine and N. Couturier and Nora Bohossian and Michel C Clanet and Patrick Vermersch and J{\'e}r{\^o}me de S{\'e}ze and David Brassat},
  journal={European journal of neurology},
  year={2014},
  volume={21 1},
  pages={40-8}
}
BACKGROUND AND PURPOSE BIONAT is a French multicentric phase IV study of natalizumab (NTZ)-treated relapsing-remitting multiple sclerosis (MS) patients. The purpose of this study was to collect clinical, radiological and biological data on 1204 patients starting NTZ, and to evaluate the clinical/radiological response to NTZ after 2 years of treatment. METHODS Patients starting NTZ at 18 French MS centres since June 2007 were included. Good response to NTZ was defined by the absence of… CONTINUE READING
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