A prospective longitudinal analysis of cytomegalovirus (CMV)-specific CD4+ and CD8+ T cells in kidney allograft recipients at risk of CMV infection.

@article{Eid2010APL,
  title={A prospective longitudinal analysis of cytomegalovirus (CMV)-specific CD4+ and CD8+ T cells in kidney allograft recipients at risk of CMV infection.},
  author={Albert J Eid and Robert A.M. Brown and Supha K Arthurs and Brian D. Lahr and Jeanette E. Eckel-Passow and Timothy S. Larson and Raymund Rabe Razonable},
  journal={Transplant international : official journal of the European Society for Organ Transplantation},
  year={2010},
  volume={23 5},
  pages={506-13}
}
Cytomegalovirus (CMV)-specific cellular immunity is essential in controlling CMV infection after transplantation. We investigated whether CMV-specific T cell levels predict CMV DNAemia after kidney transplantation. Using cytokine-flow cytometry, we enumerated interferon-gamma producing CMV-specific CD4+ and CD8+ T cells at serial time points among CMV-mismatched (D+/R-) and seropositive (R+) kidney recipients who received 3 months of valganciclovir prophylaxis. Among 44 patients, eight (18… CONTINUE READING
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