A prospective follow-up of patients with bipolar and primary unipolar affective disorder.

@article{Winokur1993APF,
  title={A prospective follow-up of patients with bipolar and primary unipolar affective disorder.},
  author={George Winokur and William H. Coryell and Martin B. Keller and Jean M Endicott and Hagop Souren Akiskal},
  journal={Archives of general psychiatry},
  year={1993},
  volume={50 6},
  pages={457-65}
}
OBJECTIVE As part of the National Institute of Mental Health Collaborative Study of the Psychobiology of Depression, the comparative course of manic depressive (bipolar) and primary unipolar patients was assessed. DESIGN Systematic evaluation using structured instruments every 6 months for a period of 5 years with the recording of remissions, new episodes, and subsequent hospitalizations. PATIENTS The number of subjects varied somewhat depending on the analyses conducted. For a comparison… CONTINUE READING

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