A prospective evaluation of ifosfamide-related nephrotoxicity in children and young adults.

  title={A prospective evaluation of ifosfamide-related nephrotoxicity in children and young adults.},
  author={Pham Thi Thu Ho and Kim Zimmerman and Leonard H. Wexler and Susan Blaney and Paul F Jarosinski and L Weaver-McClure and Shai Izraeli and Frank M Balis},
  volume={76 12},
BACKGROUND Ifosfamide has been associated with proximal renal tubular dysfunction resembling Fanconi-like syndrome and leading to rickets in young children. The characteristic manifestations of this nephrotoxicity include phosphaturia and hypophosphatemia, glycosuria, aminoaciduria, renal tubular acidosis, and urinary loss of low molecular weight serum proteins. However, the relationship between acute ifosfamide nephrotoxicity, which is frequently subclinical, and long term renal damage is… CONTINUE READING


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