A prospective double-blind clinically controlled multicenter trial of sodium pentosanpolysulfate in the treatment of interstitial cystitis and related painful bladder disease.

@article{HolmBentzen1987APD,
  title={A prospective double-blind clinically controlled multicenter trial of sodium pentosanpolysulfate in the treatment of interstitial cystitis and related painful bladder disease.},
  author={Merete Holm-Bentzen and Flemming Jacobsen and Benni Nerstr{\o}m and Gunnar Lose and J{\o}rgen Kvist Kristensen and Rita Pedersen and Torben Krarup and J. G. W. Feggetter and Patrick Bates and Rochelle Barnard},
  journal={The Journal of urology},
  year={1987},
  volume={138 3},
  pages={
          503-7
        }
}
Painful bladder disease, sensory bladder disease, chronic abacterial cystitis and interstitial cystitis are ill-defined conditions of unknown etiology and pathogenesis, and, therefore, they are without any rational therapy. Pathogenetic theories concerning defects in the epithelium and/or mucous surface coat (including glycosaminoglycans) of the bladder, and theories concerning immunological disturbances predominate. Sodium pentosanpolysulfate (Elmiron) acts by substituting a defective… CONTINUE READING
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