A prospective comparison of malaria with other severe diseases in African children: prognosis and optimization of management.

@article{Planche2003APC,
  title={A prospective comparison of malaria with other severe diseases in African children: prognosis and optimization of management.},
  author={Tim Planche and Tsiri Agbenyega and George Bedu-Addo and Daniel Ansong and Alex Owusu-Ofori and Frank Botsi Micah and Cyclopea Anakwa and Emmanuel Asafo-Agyei and Alan David Hutson and Peter W. Stacpoole and Sanjeev Krishna},
  journal={Clinical infectious diseases : an official publication of the Infectious Diseases Society of America},
  year={2003},
  volume={37 7},
  pages={
          890-7
        }
}
  • T. Planche, T. Agbenyega, +8 authors S. Krishna
  • Published 1 October 2003
  • Medicine
  • Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
The burden of malaria in regions of high endemicity frequently overwhelms hospitals' capacity to provide effective care. A rapid, simple method of identifying children who are at highest risk is vital to reduce mortality among hospitalized children. Multiple regression analysis identified prognostic variables predicting mortality in severely ill children admitted to a Ghanaian teaching hospital. These variables were compared in children with and without malaria. A total of 1492 (90.2%) of 1654… 
View on PubMed
doi.org
62 Citations
Background Citations
24
Methods Citations
1
Results Citations
4

62 Citations

Citation Type

Citation Type

Life-Threatening Malaria in African Children: A Prospective Study in a Mesoendemic Urban Setting
TLDR
These findings delineate the patterns of severe malaria in children in a West African mesoendemic urban setting and validate practicable prognostic indicators of life-threatening malaria for use in the limited facilities available in African health centers and provide a frame of reference for further research addressing life- threatening malaria in this setting.
In-hospital risk estimation in children with malaria--early predictors of morbidity and mortality.
BACKGROUND Rapid diagnosis and adequate therapy are crucial to prevent development of severe disease and death in children suffering from malaria. A reliable but easy system for disease severity…
Overdiagnosis of malaria in patients with severe febrile illness in Tanzania: a prospective study
TLDR
In Tanzania, malaria is commonly overdiagnosed in people presenting with severe febrile illness, especially in those living in areas with low to moderate transmission and in adults, with a failure to treat alternative causes of severe infection.
The prognostic value of measures of acid/base balance in pediatric falciparum malaria, compared with other clinical and laboratory parameters.
  • C. Newton, C. Valim, +4 authors T. Taylor
  • Medicine
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • 2005
TLDR
Severe falciparum malaria may be readily recognized in children at admission to hospitals in sub-Saharan Africa with use of simple, inexpensive means and does not require knowledge of lactate concentration and base excess.
Severe falciparum malaria in Gabonese children: clinical and laboratory features
TLDR
The prognostic indicators of severe falciparum malaria in Gabonese children were coma/seizures, hyperlactataemia and hypoglycaemia, and the highest case fatality rate was in children with all three of these features.
Clinical Indicators for Bacterial Co-Infection in Ghanaian Children with P. falciparum Infection
TLDR
The results demonstrate the limitation of clinical symptoms to determine bacterial co-infections in P. falciparum infected children and suggest rapid testing for distinguishing parasitemia and bacteremia is essential.
Clinical Features and Outcome in Children with Severe Plasmodium falciparum Malaria: A Meta-Analysis
TLDR
Significant geographic differences in the complication rates and subsequent CFRs exist and provide the first robust confirmation of lower CFRs in Melanesian children, perhaps due to less frequent HG.
Malaria in rural Mozambique. Part II: children admitted to hospital
TLDR
Malaria remains the number one cause of admission in rural Mozambique, predominantly affecting young children, which are also at higher risk of dying, and measures envisaged to protect children during their first two years of life are likely to have a greater impact than at any other age.
Cardiac function and hemodynamics in Kenyan children with severe malaria
TLDR
Children with severe malaria and metabolic acidosis have evidence of hypovolemia and evidence of cardiac dysfunction, including severe tachycardia, low stroke volume index, and high inferior vena cava collapsibility index, which improved with subsequent readings.
Complicated malaria and other severe febrile illness in a pediatric ward in Libreville, Gabon
TLDR
The use of clinical symptoms for the management of children febrile illness is frequent in Gabon and antibiotics were frequently prescribed without bacteriological confirmation.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 33 REFERENCES
Indicators of life-threatening malaria in African children.
TLDR
In African children with malaria, the presence of impaired consciousness or respiratory distress can identify those at high risk for death.
Clinical features and outcome of severe malaria in Gambian children.
  • D. Waller, S. Krishna, +7 authors P. Holloway
  • Medicine
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • 1995
TLDR
The clinical and laboratory features of severe falciparum malaria in 180 Gambian children were studied and neurological status (coma, particularly if associated with extensor posturing), stage of parasite development on the peripheral blood film, pulse rate, hypoglycemia, and hyperlactatemia were identified as independent indicators of a fatal outcome.
Clinical features and prognostic indicators in paediatric cerebral malaria: a study of 131 comatose Malawian children.
TLDR
A prognostic index based on eight risk factors that can readily be ascertained at the bedside or in a ward sideroom, was more accurately predictive of outcome than any single feature.
Severe malaria in children in Papua New Guinea.
TLDR
Coma was not predictive of death, although a high proportion of children with profound coma died, and emphasis must be placed on the prevention or early recognition and treatment of acidosis in the district health clinic as well as the central hospital.
Predictors of a fatal outcome following childhood cerebral malaria.
TLDR
A combination of clinical and laboratory abnormalities can identify a group of children with cerebral malaria who are most at risk of dying, who require intensive care and who are candidates for new forms of therapy.
Acid-base status in paediatric Plasmodium falciparum malaria.
TLDR
The strong association of altered acid-base status with disease severity and mortality was independent of other previously identified predictors of illness and death in malaria and acidaemia was not associated with shock, bacteraemia or hypoxaemia.
Lactic acidosis and hypoglycaemia in children with severe malaria: pathophysiological and prognostic significance.
The ears of the hippopotamus: manifestations, determinants, and estimates of the malaria burden.
  • J. Breman
  • Medicine
    The American journal of tropical medicine and hygiene
  • 2001
TLDR
To decrease and stop transmission of this intolerable scourge, there is an urgent need for malaria vaccines, newer drugs, and better vector control methods as well as the ability to improve current technologies and use them more efficiently.
Effect of iron chelation therapy on mortality in Zambian children with cerebral malaria.
Comparison of methods for the rapid laboratory assessment of children with malaria.
TLDR
An accurate and rapid alternative to conventional thick film examination (Lambaréné method) and near-patient methods for measuring blood glucose and lactate (OneTouch and Accusport).
...
1
2
3
4
...