A prospective cohort study to determine the relationship between serum infliximab concentration and efficacy in patients with luminal Crohn's disease.

@article{Levesque2014APC,
  title={A prospective cohort study to determine the relationship between serum infliximab concentration and efficacy in patients with luminal Crohn's disease.},
  author={Barrett G. Levesque and Gordon R. Greenberg and Guang Yong Zou and W J Sandborn and Siddharth Singh and Scott I Hauenstein and Linda Ohrmund and Cindy J. Wong and Larry W. Stitt and L M Shackelton and Debra H King and Steve Lockton and Jaylene Ducharme and Brian G Feagan},
  journal={Alimentary pharmacology & therapeutics},
  year={2014},
  volume={39 10},
  pages={1126-35}
}
BACKGROUND Patients with Crohn's disease (CD) may experience disease relapse on maintenance infliximab. Anti-drug antibodies likely contribute to loss of response, and serum infliximab levels likely correlate with efficacy. AIM To prospectively evaluate the relationship between trough serum infliximab concentration and disease activity. METHODS Adult patients (N = 327) with a diagnosis of CD who had received at least five consecutive infliximab infusions and who planned to receive at least… CONTINUE READING
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