A prospective cohort study of childhood behavioral deviance and language abnormalities as predictors of adult schizophrenia.

@article{Bearden2000APC,
  title={A prospective cohort study of childhood behavioral deviance and language abnormalities as predictors of adult schizophrenia.},
  author={Carrie E. Bearden and Isabelle M. Rosso and J. Megginson Hollister and L E Sanchez and Trevor Hadley and Tyrone D. Cannon},
  journal={Schizophrenia bulletin},
  year={2000},
  volume={26 2},
  pages={
          395-410
        }
}
Language and behavioral deviance in early childhood in preschizophrenia individuals suggests that the pathologic processes predisposing to schizophrenia are present from early in life. However, the etiologic antecedents of such impairments, and the degree to which they predict adult schizophrenia, have not been conclusively demonstrated. To address this, we examined language and behavioral predictors of adult psychiatric outcome in a population cohort (72 individuals with schizophrenia or… 
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149 Citations
Highly Influential Citations
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Background Citations
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Methods Citations
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149 Citations

Evidence for early-childhood, pan-developmental impairment specific to schizophreniform disorder: results from a longitudinal birth cohort.
TLDR
Evidence is provided for an early-childhood, persistent, pan-developmental impairment that is specifically associated with schizophreniform disorder and that predicts psychotic symptoms in childhood and adulthood.
Premorbid multivariate markers of neurodevelopmental instability in the prediction of adult schizophrenia-spectrum disorder: a high-risk prospective investigation
PRE-ONSET ABNORMALITIES, PSYCHOSOCIAL STRESSORS, AND THE DEVELOPMENT OF PSYCHOSIS: A PROSPECTIVE, POPULATION-BASED STUDY
TLDR
The utility of assessing both level of and patterns of change over time on indices of functioning when attempting to identify and characterize the functioning of individuals at risk for psychosis development is underscored.
Childhood developmental abnormalities in schizophrenia: evidence from high-risk studies
Community screening for psychotic-like experiences and other putative antecedents of schizophrenia in children aged 9–12 years
The interplay of childhood behavior problems and IQ in the development of later schizophrenia and affective psychoses
Relationship between clinical and neuropsychological characteristics in child and adolescent first degree relatives of subjects with schizophrenia
Development of social functioning in preschizophrenia children and adolescents: a systematic review.
TLDR
The results indicate that poor social functioning does differentiate preschizophrenia children and adolescents from their peers and can be a sensitive and potentially specific predictor of schizophrenia, not just psychopathology in general.
Early language measures associated with later psychosis features in 22q11.2 deletion syndrome.
  • C. Solot, T. Moore, R. Gur
  • Psychology, Medicine
    American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
  • 2020
TLDR
It is suggested that while preschool language testing is useful in characterizing performance decline in individuals with 22q11DS, it does not robustly differentiate those with subsequent PS from those without, however, language testing in the school age population can help identify individuals with 21st Century psychosis who are at risk for psychosis.
A prospective study of childhood neurocognitive functioning in schizophrenic patients and their siblings.
TLDR
Children who later developed schizophrenia and their siblings showed similar patterns of deficits involving spatial reasoning, verbal knowledge, perceptual-motor speed, and speeded processes of working memory, however, the probands exhibited more severe deficits in perceptual-Motor speed and speeding processes ofWorking memory than their unaffected siblings.
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References

SHOWING 1-10 OF 59 REFERENCES
Childhood neuromotor dysfunction in schizophrenia patients and their unaffected siblings: a prospective cohort study.
TLDR
Deviance on motor coordination measures at 7 years was associated with both adult schizophrenia and unaffected sibling status, suggesting that a cofamilial (and perhaps genetic) factor underlies motor coordination deficits in schizophrenia.
Infant predictors of the longitudinal course of schizophrenic development.
  • B. Fish
  • Psychology, Medicine
    Schizophrenia bulletin
  • 1987
TLDR
Primary prevention requires research into the mechanisms underlying these dysfunctions in infancy, and specific neurointegrative disorders in infancy predict vulnerability to later schizophrenia and schizotypal disorder.
Child developmental risk factors for adult schizophrenia in the British 1946 birth cohort
A prospective cohort study of genetic and perinatal influences in the etiology of schizophrenia.
TLDR
It is found that the odds of schizophrenia increased linearly with increasing number of hypoxia-associated OCs and that this effect was specific to cases with an early age at onset/first treatment contact, suggesting that Hypoxia acts additively or interactively with genetic factors in influencing liability to schizophrenia.
Familial, obstetric, and other clinical correlates of minor physical anomalies in schizophrenia.
TLDR
Minor physical anomalies indicate early dysmorphogenesis in schizophrenia, particularly in males, which appears to be associated more reliably with genetic rather than obstetric factors and with cognitive impairment.
Childhood behavior precursors of schizotypal personality disorder.
TLDR
It is suggested that preschizotypal traits may be identified in late childhood or adolescence, and the ability of these factors to predict future SPDs is comparable for males and females.
Speech and language disorders in children and adolescents with schizophrenia.
TLDR
The communication deficits identified in the early-onset group closely resembled the phenomenology reported in studies of the communication characteristics of adults with schizophrenia, which lends further support to the presence of the same disorder as seen in adults.
Risk factors in schizophrenia: the Stony Brook High-Risk Project.
TLDR
Considerable deviance in family functioning, expressed in conflict, marital discord, and parenting skills, was characteristic of the families with an ill parent, and this discord was related to child adjustment.
Language processing and memory in ill and well siblings from multiplex families affected with schizophrenia
Prenatal origin of schizophrenia in a subgroup of discordant monozygotic twins.
TLDR
It is concluded that some cases of adult-onset schizophrenia are associated with prenatal events, which may include neurodevelopmental abnormalities or specific insults such as anoxia or infectious agents.
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