A prospective case-control study analyzes 12 thrombophilic gene mutations in Turkish couples with recurrent pregnancy loss.

@article{Yenicesu2010APC,
  title={A prospective case-control study analyzes 12 thrombophilic gene mutations in Turkish couples with recurrent pregnancy loss.},
  author={Gonca Imir Yenicesu and Meral Çetin and Ozturk Ozdemir and Ali Emrah Çetin and Filiz Ozen and Cem Yenicesu and Caglar Yildiz and Nadir Koçak},
  journal={American journal of reproductive immunology},
  year={2010},
  volume={63 2},
  pages={126-36}
}
PROBLEM Recurrent pregnancy loss (RPL) is a heterogeneous disorder. The contribution of specific thrombophilic genes to the pathophysiology of RPL has remained controversial. We evaluated the prevalences of 12 thrombophilic gene mutations among homogenous Caucasian couples with RPL and fertiles. METHOD of study This was a prospective case-control study evaluating 272 women with RPL and 152 of their male partners, and a control group of 56 fertile couples. We investigated mutations including… CONTINUE READING