A prospective, randomized pilot trial of model-based warfarin dose initiation using CYP2C9 genotype and clinical data.

@article{Hillman2005APR,
  title={A prospective, randomized pilot trial of model-based warfarin dose initiation using CYP2C9 genotype and clinical data.},
  author={Michael A Hillman and Russell A. Wilke and Steven H Yale and Humberto J. Vidaillet and Michael D. Caldwell and Ingrid Glurich and Richard L. Berg and John R. Schmelzer and James K. Burmester},
  journal={Clinical medicine & research},
  year={2005},
  volume={3 3},
  pages={
          137-45
        }
}
BACKGROUND Rapid genetic screening for cytochrome P450 (CYP) 2C9 variants may play a role in improving the efficacy and safety of warfarin in individuals with CYP2C9 variants. The feasibility of prospective CYP2C9 model-based warfarin dosing has not yet been assessed. OBJECTIVES To evaluate the feasibility of applying a CYP2C9 gene-based warfarin dosing model in clinical practice. DESIGN Prospective, randomized, single-blinded clinical pilot trial. SETTING Large multispecialty group… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 92 CITATIONS, ESTIMATED 51% COVERAGE

Genotype-Based Dosing Algorithms for Warfarin Therapy

VIEW 7 EXCERPTS
CITES RESULTS, BACKGROUND & METHODS
HIGHLY INFLUENCED

Enzyme Polymorphism in Warfarin Dose Management After Pediatric Cardiac Surgery

VIEW 4 EXCERPTS
CITES BACKGROUND & RESULTS
HIGHLY INFLUENCED

Optimal loading dose for the initiation of warfarin: a systematic review

VIEW 6 EXCERPTS
CITES BACKGROUND & METHODS
HIGHLY INFLUENCED

FILTER CITATIONS BY YEAR

2005
2020

CITATION STATISTICS

  • 11 Highly Influenced Citations

References

Publications referenced by this paper.
SHOWING 1-10 OF 14 REFERENCES

Assessing impact of organizational interventions – Marshfield Clinic ’ s Coumadin Clinic Evaluation : Final Report

  • MK Higashi, DL Veenstra
  • 2001