A prospective, randomized, comparative trial evaluating respiratory depression during patient-controlled versus anesthesiologist-administered propofol-remifentanil sedation for elective colonoscopy.

@article{Mandel2010APR,
  title={A prospective, randomized, comparative trial evaluating respiratory depression during patient-controlled versus anesthesiologist-administered propofol-remifentanil sedation for elective colonoscopy.},
  author={J. Elizabeth Mandel and Gary R. Lichtenstein and David C. Metz and Gregory G. Ginsberg and Michael L. Kochman},
  journal={Gastrointestinal endoscopy},
  year={2010},
  volume={72 1},
  pages={112-7}
}
BACKGROUND Patient-controlled sedation (PCS) with propofol-remifentanil (PR) is associated with rapid sedation and recovery, but it is associated with a greater requirement for airway rescue than PCS with midazolam-fentanyl. OBJECTIVE To demonstrate that respiratory depression associated with PR is more frequent during anesthesiologist-administered sedation (AAS) than during PCS. DESIGN Prospective, randomized, open-label study. SETTING Academic medical center. PATIENTS Fifty patients… CONTINUE READING