A proposed sequence of events for cadmium-induced mitochondrial impairment.

@article{Dorta2003APS,
  title={A proposed sequence of events for cadmium-induced mitochondrial impairment.},
  author={Daniel Dorta and Samara Leite and K{\'a}tia C DeMarco and Ieda M.R. Prado and Tiago Rodrigues and F{\'a}bio E Mingatto and S{\'e}rgio Akira Uyemura and Antonio Cardozo dos Santos and Carlos Curti},
  journal={Journal of inorganic biochemistry},
  year={2003},
  volume={97 3},
  pages={251-7}
}
Cadmium is a very important environmental toxicant, the cytotoxicity mechanism of which is likely to involve mitochondria as a target. In the present study we addressed the cause/effect relationship between the multiple cadmium-induced responses involving the mitochondrial energetic and oxidative status. Assays were performed with succinate-energized rat liver mitochondria incubated with 5 microM CdCl(2) for 0-25 min, in the absence or presence, respectively, of N-ethylmaleimide (NEM… CONTINUE READING