• Corpus ID: 208475792

A proposed new therapy of tumors deficient in methylthioadenosine phosphorylase (MTAP)

@article{Lubin2008APN,
  title={A proposed new therapy of tumors deficient in methylthioadenosine phosphorylase (MTAP)},
  author={M. Lubin and A. Lubin},
  journal={Cancer Research},
  year={2008},
  volume={68},
  pages={1531-1531}
}
1531 The MTAP gene lies on 9p21 and is often homozygously deleted, along with p16, in tumors -- especially lung and pancreatic cancer, glioma, mesothelioma, and sarcoma (frequency of deletion is 30-75%). We describe a new, selective therapy of such tumors. MTAP cleaves methylthioadenosine (MTA), a by-product of polyamine synthesis, to adenine and 5-methylthioribose-1-phosphate, which are then converted to adenine nucleotides and methionine. Tumors deficient in MTAP may therefore be sensitive to…