• DOI:10.1212/WNL.67.7_SUPPL_2.S8
• Corpus ID: 18497520

A proposed dual role of neuromelanin in the pathogenesis of Parkinson’s disease

@article{Zecca2006APD,
  title={A proposed dual role of neuromelanin in the pathogenesis of Parkinson’s disease},
  author={Luigi Zecca and Fabio A. Zucca and Alberto Albertini and Enrico Rizzio and Ruggero G. Fariello},
  journal={Neurology},
  year={2006},
  volume={67},
  pages={S11 - S8}
}

• L. Zecca, F. Zucca, +2 authors R. Fariello
• Published 10 October 2006
• Biology
• Neurology

In many parkinsonian syndromes, neuromelanin (NM)-containing dopaminergic neurons of the substantia nigra (SN) are selectively targeted by the noxius pathogens. Studies of the constitutional and functional features of human NM allow the formulation of a logical hypothesis on its role in parkinsonian syndromes. In the early stages, NM synthesis and iron-chelating properties may act as a powerful protective mechanism, delaying symptom appearance and/or slowing disease progression. Once these systems have been exhausted, the pathogenic mechanisms affecting cytoplasmic organelles other than NM destroy NM-harboring neurons, with consequent pouring out of NM granules. These in turn activate microglia, causing release of nitric oxide, interleukin-6 and tumor necrosis factor-α, thus becoming an important determinant of disease aggravation. Neuromelanin appears to be a suitable target for devising chemical agents that might modify the course of these diseases.