A proposed autacoid mechanism controlling mastocyte behaviour

  title={A proposed autacoid mechanism controlling mastocyte behaviour},
  author={Luigi Aloe and Alberta Leon and Rita Levi‐montalcini},
  journal={Agents and Actions},
Evidence is provided here supporting the existence of a novel autacoid mechanism negatively modulating mast cell behaviour in response to noxious stimuliin vivo; hence, the denomination “autacoid local inflammation antagonism” (ALIA). In particular, as lipid amides of theN-acylethanolamine type have been reported to accumulate in tissues in degenerative inflammatory conditions, we examined whether theseN-acylated lipids could exert regulatory effects on mast cell activationin vivo. The results… 
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