• DOI:10.1007/BF01972748
• Corpus ID: 20577242

A proposed autacoid mechanism controlling mastocyte behaviour

@article{Aloe2005APA,
  title={A proposed autacoid mechanism controlling mastocyte behaviour},
  author={Luigi Aloe and Alberta Leon and Rita Levi‐montalcini},
  journal={Agents and Actions},
  year={2005},
  volume={39},
  pages={C145-C147}
}

• L. Aloe, A. Leon, R. Levi‐montalcini
• Published 2005
• Biology
• Agents and Actions

Evidence is provided here supporting the existence of a novel autacoid mechanism negatively modulating mast cell behaviour in response to noxious stimuliin vivo; hence, the denomination “autacoid local inflammation antagonism” (ALIA). In particular, as lipid amides of theN-acylethanolamine type have been reported to accumulate in tissues in degenerative inflammatory conditions, we examined whether theseN-acylated lipids could exert regulatory effects on mast cell activationin vivo. The results reported show that both long- and short-chainN-acylethanolamines, when systemically administered, are effective in reducing mast cell degranulation induced by local injection of substance P in the earpinna of developing rats. These and other data suggest that the endogenous production ofN-acylethanolamines may constitute a local autocrine/paracrine response for the negative feedback control of mast cell responses to various activating signals. Such a process may be of physio-pathological relevance in the regulation of functional neuroimmune-mast cell interactions.