A proposed autacoid mechanism controlling mastocyte behaviour

@article{Aloe2005APA,
  title={A proposed autacoid mechanism controlling mastocyte behaviour},
  author={Luigi Aloe and Alberta Leon and Rita Levi‐montalcini},
  journal={Agents and Actions},
  year={2005},
  volume={39},
  pages={C145-C147}
}
Evidence is provided here supporting the existence of a novel autacoid mechanism negatively modulating mast cell behaviour in response to noxious stimuliin vivo; hence, the denomination “autacoid local inflammation antagonism” (ALIA). In particular, as lipid amides of theN-acylethanolamine type have been reported to accumulate in tissues in degenerative inflammatory conditions, we examined whether theseN-acylated lipids could exert regulatory effects on mast cell activationin vivo. The results… 
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References

SHOWING 1-9 OF 9 REFERENCES
The role of mast cell degranulation products in mast cell hyperplasia. I. Mechanism of action of nerve growth factor.
TLDR
The results suggest that NGF has dual action inducing mast cellhyperplasia; CTMC hyperplasia being dependent on the ability of NGF to degranulate mast cells, and that the CTMC population may be regulated by an autocrine positive feedback mechanism in vivo.
Nerve growth factor in the synovial fluid of patients with chronic arthritis.
TLDR
NGF was present in the synovial fluid and synovium of patients with chronic arthritis, but was undetectable in control fluids, suggesting that NGF might be involved in the pathogenesis of arthritis.
Cytokine production by mast cells and basophils
  • 1991
A role for nerve growth factor in nervous , endocrine and immune system
  • Semin . Immunopathol .
The role of mast cell degranulation in mast cell hyperplasia , I . Mechanism of action of nerve growth factor . 3
  • Brain Res .
  • 1977
Cytokineproduction by mast cells and basophils
  • Immunol .
  • 1990