• DOI:10.1021/ja207065v
Corpus ID: 38845409

A proposal for mitochondrial processing peptidase catalytic mechanism.

@article{Amata2011APF,
  title={A proposal for mitochondrial processing peptidase catalytic mechanism.},
  author={Orazio Amata and T. Marino and N. Russo and M. Toscano},
  journal={Journal of the American Chemical Society},
  year={2011},
  volume={133 44},
  pages={
          17824-31
        }
}

• Orazio Amata, T. Marino, +1 author M. Toscano
• Published 2011
• Chemistry, Medicine
• Journal of the American Chemical Society

The reaction mechanism of the Mitochondrial Processing Peptidase enzyme (MPP) was investigated by using hybrid density functional theory. This enzyme removes the NH(2)-terminal targeting signals of nuclear-encoded mitochondrial protein precursors in the mitochondrial matrix. The catalytic process was studied using a model for the active site consisting of 161 atoms locating all the stationary points on the potential energy curve and determining the main energetic, structural, and electronic… Expand

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