A proportion of patients with lymphoma may harbor mutations of the perforin gene.

@article{Clementi2005APO,
  title={A proportion of patients with lymphoma may harbor mutations of the perforin gene.},
  author={Rita Clementi and Franco Locatelli and Lo{\"i}c Dupr{\'e} and Alberto Garaventa and Lorenzo Emmi and Marco Bregni and Graziella S Cefalo and Antonia Moretta and Cesare Danesino and Margherita Comis and Andrea Pession and Ugo Ramenghi and Rita Maccario and M. Rita Aric{\`o} and Maria Grazia Roncarolo},
  journal={Blood},
  year={2005},
  volume={105 11},
  pages={4424-8}
}
Perforin mutations have been demonstrated in a proportion of patients diagnosed with the familial form of hemophagocytic lymphohistiocytosis (HLH). In the present study, we evaluated whether some patients with lymphoma sharing clinical characteristics with HLH might harbor mutations of the perforin gene. We analyzed 29 patients and found that 4 patients… CONTINUE READING