A propensity score case-control comparison of aprotinin and tranexamic acid in high-transfusion-risk cardiac surgery.


BACKGROUND Cardiac surgery with cardiopulmonary bypass may result in excessive fibrinolysis and platelet (PLT) dysfunction, resulting in impaired hemostasis and excessive blood loss. Prophylactic use of the antifibrinolytic drugs aprotinin and tranexamic acid is thought to prevent these hemostatic defects. Their relative clinical utility and safety in high… (More)


  • Presentations referencing similar topics