A proof-of-concept study of the effect of a novel H3-receptor antagonist in allergen-induced nasal congestion.

@article{Barchuk2013APS,
  title={A proof-of-concept study of the effect of a novel H3-receptor antagonist in allergen-induced nasal congestion.},
  author={William T. Barchuk and Anne Marie F. Salapatek and Tingting Ge and Pina D'Angelo and Xuejun Liu},
  journal={The Journal of allergy and clinical immunology},
  year={2013},
  volume={132 4},
  pages={
          838-46.e1-6
        }
}
BACKGROUND H1-receptor inverse agonists are used effectively for treating several symptoms of allergic rhinitis, including nasal itching, rhinorrhea, and sneezing, although most agents are not very effective in treating nasal congestion. OBJECTIVE This study evaluated the relative efficacy of a novel selective H3-receptor antagonist, JNJ-39220675, in preventing nasal congestion induced by exposing participants with ragweed allergy to ragweed allergen in an environmental exposure chamber model… CONTINUE READING
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International Union of Basic and Clinical Pharmacology. XCVIII. Histamine Receptors.

  • Pharmacological reviews
  • 2015
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Novel, Alternative, and Controversial Therapies of Rhinitis.

  • Immunology and allergy clinics of North America
  • 2016
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