A promoter relay mechanism for sequential gene activation.

@article{Fang1998APR,
  title={A promoter relay mechanism for sequential gene activation.},
  author={M. Fang and Huantao Wu},
  journal={Journal of bacteriology},
  year={1998},
  volume={180 3},
  pages={626-33}
}
The effect of DNA supercoiling on gene expression is dependent not only on specific genes but also on the sequence context of the genes. This position-dependent supercoiling effect on gene activation is best illustrated in the study of the suppression of the leu-500 mutation of the leuABCD operon in a Salmonella typhimurium topA mutant. In this communication, we report a novel promoter relay mechanism whereby several genes are sequentially expressed in a position-dependent manner: the ilvIH… CONTINUE READING

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The leucine/Lrp regulon, p. 1513–1525

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