A promoter polymorphism in the gene encoding interleukin-12 p40 (IL12B) is associated with mortality from cerebral malaria and with reduced nitric oxide production

@article{Morahan2002APP,
  title={A promoter polymorphism in the gene encoding interleukin-12 p40 (IL12B) is associated with mortality from cerebral malaria and with reduced nitric oxide production},
  author={Grant Morahan and Craig Steven Boutlis and Deren Huang and Arnab Pain and Jocelyn R. Saunders and Maurine R. Hobbs and Donald L. Granger and J Brice Weinberg and Norbert Peshu and Esther D. Mwaikambo and Kevin Marsh and David J Roberts and Nicholas M Anstey},
  journal={Genes and Immunity},
  year={2002},
  volume={3},
  pages={414-418}
}
Interleukin-12 (IL-12) is an important regulatory cytokine in infection and immunity. Administration of IL-12 may reduce complications of severe malaria in rodents. Polymorphisms in IL12B, the gene encoding the IL-12 p40 subunit, influence the secretion of IL-12 and susceptibility to Type 1 diabetes. We therefore investigated whether IL12B polymorphisms may affect the outcome of severe malaria. Homozygosity for a polymorphism in the IL12B promoter was associated with increased mortality in… CONTINUE READING
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structure, chromosomal localisation, and definition of polymorphisms of the gene encoding the human interleukin-12 p40 subunit

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