A prolonged protein kinase C-mediated, opioid-related antinociceptive effect of st John's Wort in mice.

UNLABELLED The antinociceptive profile of St. John's Wort (SJW) was investigated in mice in a condition of acute thermal and chemical pain, together with the mechanism that might underlie this effect. A dried extract of SJW induced a prolonged antinociception that persisted for 120 minutes after administration. The thermal antinociception was prevented by… CONTINUE READING