A proline residue in the alpha-helical rod domain of type I keratin 16 destabilizes keratin heterotetramers.

Abstract

The type I keratins 14 (K14) and 16 (K16) are distinct in their assembly properties and their expression pattern despite a high degree of sequence identity. Understanding K16 function and regulation is of interest, given its strong induction in keratinocytes located at the wound edge after injury to stratified epithelia. We reported previously that… (More)

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