A proliferation-inducing ligand (APRIL) is expressed by astrocytes and is increased in multiple sclerosis.

@article{Thangarajh2007APL,
  title={A proliferation-inducing ligand (APRIL) is expressed by astrocytes and is increased in multiple sclerosis.},
  author={Mathula Thangarajh and Thomas Masterman and Jan Hillert and Sverre J. M{\"o}rk and Roland Jonsson},
  journal={Scandinavian journal of immunology},
  year={2007},
  volume={65 1},
  pages={92-8}
}
A proliferation-inducing ligand (APRIL) is a newly described member of the tumour necrosis factor (TNF) superfamily that was first identified as a factor favouring tumorigenesis. APRIL is also important for several immune functions, including B-cell survival. Multiple sclerosis (MS) is an inflammatory, demyelinating disease of the central nervous system (CNS) that is commonly diagnosed in early adulthood. Several TNF superfamily members have been identified in brains of patients with MS… CONTINUE READING

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