A proliferation gradient between proximal and msxb-expressing distal blastema directs zebrafish fin regeneration.

@article{Nechiporuk2002APG,
  title={A proliferation gradient between proximal and msxb-expressing distal blastema directs zebrafish fin regeneration.},
  author={Alex Nechiporuk and Mark T. Keating},
  journal={Development},
  year={2002},
  volume={129 11},
  pages={2607-17}
}
Previous studies of zebrafish fin regeneration led to the notion that the regeneration blastema is a homogeneous population of proliferating cells. Here, we show that the blastema consists of two components with markedly distinct proliferation properties. During early blastema formation, proliferating cells are evenly distributed. At the onset of regenerative outgrowth, however, blastemal cells are partitioned into two domains. Proximal blastemal cells proliferate at a high rate, shifting from… CONTINUE READING
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