A prokaryote and human tRNA synthetase provide an essential RNA splicing function in yeast mitochondria.

@article{Houman2000APA,
  title={A prokaryote and human tRNA synthetase provide an essential RNA splicing function in yeast mitochondria.},
  author={F Houman and Seung Bae Rho and Junfang Zhang and Xiling Shen and Ching Chiung Wang and Paul R. Schimmel and Susan A. Martinis},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2000},
  volume={97 25},
  pages={13743-8}
}
Mitochondrial leucyl-tRNA synthetase (LeuRS) in the yeast Saccharomyces cerevisiae provides two essential functions. In addition to aminoacylation, LeuRS functions in RNA splicing. The details of how it came to act in splicing are not known. Here we show that Mycobacterium tuberculosis and human mitochondrial LeuRSs can substitute in splicing for the S. cerevisiae mitochondrial LeuRS. Mutations of yeast mitochondrial LeuRS that had previously been shown to abolish splicing activity also… CONTINUE READING
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