A prognostic scoring system based on clinical features of intrahepatic cholangiocarcinoma: the Fudan score.


BACKGROUND The objectives of this study were to propose a clinical prognostic scoring system applicable for intrahepatic cholangiocarcinoma (ICC) and to evaluate the prognostic validity of the American Joint Committee on Cancer (AJCC) 7th edition staging system. PATIENTS AND METHODS Retrospective univariate and multivariate survival analyses were conducted for 344 patients with ICC who underwent hepatectomy. A simple clinical prognostic scoring system (Fudan score) was developed based on the independent predictors. The prognostic validity was assessed in 74 patients with unresected tumors and compared with the AJCC 6th and 7th edition systems. RESULTS In the training set, serum alkaline phosphatase level, carbohydrate antigen 19-9 level, tumor boundary type, tumor size, and number of intrahepatic tumors were independent predictive factors of survival in ICC and were incorporated into the Fudan score. Three hundred forty-four patients were categorized into four subsets with 5-year overall survival rates of 48.6%, 25.6%, 10.3%, and 0.0% for low-, intermediate-, high-, and extremely high-risk groups, respectively. The discriminative ability of the Fudan score was better than that of the AJCC staging system and well applied in the unresected patient set. CONCLUSIONS A Fudan score based on clinical factors may provide a relatively accurate prognostic prediction for ICC patients regardless of resection status.

DOI: 10.1093/annonc/mdq650
Citations per Year

159 Citations

Semantic Scholar estimates that this publication has 159 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Jiang2011APS, title={A prognostic scoring system based on clinical features of intrahepatic cholangiocarcinoma: the Fudan score.}, author={Weijian Jiang and Zhao-Chong Zeng and Z M Tang and J. Fan and H C Sun and J Zhou and M D Zeng and B H Zhang and Yonghua Ji and Y Y Chen}, journal={Annals of oncology : official journal of the European Society for Medical Oncology}, year={2011}, volume={22 7}, pages={1644-52} }