A profound decrease in maternal arginine uptake provokes endothelial nitration in the pregnant rat.

@article{Reshef2008APD,
  title={A profound decrease in maternal arginine uptake provokes endothelial nitration in the pregnant rat.},
  author={Ran Reshef and Doron Schwartz and Merav Ingbir and Alexander Shtabsky and Tamara Chernichovski and Benjamin Alkan Isserlin and Gil Chernin and Yoram Levo and Idit Feenberg Schwartz},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2008},
  volume={294 3},
  pages={
          H1156-63
        }
}
While a specific role for nitric oxide (NO) in inducing the hemodynamic alterations of pregnancy is somewhat controversial, it is widely accepted that excess NO is generated during pregnancy. L-Arginine is the sole precursor for NO biosynthesis. Among several transporters that mediate L-arginine uptake, cationic amino acid transporter-1 (CAT-1) acts as the specific arginine transporter for endothelial NO synthase. The present study was designed to test the hypothesis that, during pregnancy… CONTINUE READING

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