A profile of fertilization in mammals

  title={A profile of fertilization in mammals},
  author={Paul M Wassarman and Luca Jovine and Eveline S. Litscher},
  journal={Nature Cell Biology},
Fertilization is defined as the process of union of two gametes, eggs and sperm. When mammalian eggs and sperm come into contact in the female oviduct, a series of steps is set in motion that can lead to fertilization and ultimately to development of new individuals. The pathway begins with species-specific binding of sperm to eggs and ends a relatively short time later with fusion of a single sperm with each egg. Although this process has been investigated extensively, only recently have the… 

The molecular players of sperm-egg fusion in mammals.

Molecules that function in the steps of fertilization.

Egg-sperm interactions at fertilization in mammals.

Penetration, Adhesion, and Fusion in Mammalian Sperm-Egg Interaction

Fertilization is the sum of the cellular mechanisms that pass the genome from one generation to the next and initiate development of a new organism and the gamete molecules and molecular interactions with essential roles in these events are gradually being discovered.

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The cell and molecular biology of mammalian fertilization is discussed, selected recent breakthroughs are highlighted and key unanswered questions are identified.

When a sperm meets an egg: Block to polyspermy




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The unique nature, highly restricted expression, and multiple roles of ZP3 during mammalian development make this glycoprotein a particularly attractive subject for investigation at both the cellular and molecular levels.

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Fate of Nonfertilizing Spermatozoa and Interaction of Spermutozoa with Somatic Cells and Fate of nonfertility-related events are studied.

Molecules involved in mammalian sperm-egg interaction.

Do human eggs attract spermatozoa?

It is demonstrated that human sperm chemotaxis to a follicular factor(s) does occur, at least in vitro, and that only capacitated spermatozoa are chemotactically responsive.

Ion channels in sperm physiology.

The multi-faceted approach being used to unravel sperm ion channel function and regulation is yielding valuable information about the finely orchestrated events that lead to sperm activation, induction of the acrosome reaction, and in the end to the miracle of life.

Fertilization defects in sperm from mice lacking fertilin beta.

Fertilin, a member of the ADAM family, is found on the plasma membrane of mammalian sperm and could have a direct role in sperm-zona binding or oviduct migration; alternatively, the effects on these functions could result from the absence of fertilin activity during spermatogenesis.