A proficient enzyme.

@article{Radzicka1995APE,
  title={A proficient enzyme.},
  author={Anna Radzicka and Richard Wolfenden},
  journal={Science},
  year={1995},
  volume={267 5194},
  pages={
          90-3
        }
}
Orotic acid is decarboxylated with a half-time (t1/2) of 78 million years in neutral aqueous solution at room temperature, as indicated by reactions in quartz tubes at elevated temperatures. Spontaneous hydrolysis of phosphodiester bonds, such as those present in the backbone of DNA, proceeds even more slowly at high temperatures, but the heat of activation is less positive, so that dimethyl phosphate is hydrolyzed with a t1/2 of 130,000 years in neutral solution at room temperature. These… 
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