A product of independent beta probabilities dose escalation design for dual-agent phase I trials

@inproceedings{Mander2015APO,
  title={A product of independent beta probabilities dose escalation design for dual-agent phase I trials},
  author={Adrian P Mander and Michael J Sweeting},
  booktitle={Statistics in medicine},
  year={2015}
}
Dual-agent trials are now increasingly common in oncology research, and many proposed dose-escalation designs are available in the statistical literature. Despite this, the translation from statistical design to practical application is slow, as has been highlighted in single-agent phase I trials, where a 3 + 3 rule-based design is often still used. To expedite this process, new dose-escalation designs need to be not only scientifically beneficial but also easy to understand and implement by… CONTINUE READING
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