A processed form of the Spätzle protein defines dorsal-ventral polarity in the Drosophila embryo.

@article{Schneider1994APF,
  title={A processed form of the Sp{\"a}tzle protein defines dorsal-ventral polarity in the Drosophila embryo.},
  author={David S Schneider and Ye Jin and Donald Morisato and Kathryn V Anderson},
  journal={Development},
  year={1994},
  volume={120 5},
  pages={1243-50}
}
Stein et al. (1991) identified a soluble, extracellular factor that induces ventral structures at the site where it is injected in the extracellular space of the early Drosophila embryo. This factor, called polarizing activity, has the properties predicted for a ligand for the transmembrane receptor encoded by the Toll gene. Using a bioassay to follow activity, we purified a 24 x 10(3) M(r) protein that has polarizing activity. The purified protein is recognized by antibodies to the C-terminal… CONTINUE READING