A procedure for the isolation of specific point mutants of influenza virus.

@article{Mitchell1993APF,
  title={A procedure for the isolation of specific point mutants of influenza virus.},
  author={Brianna M. Mitchell and D C Deborde},
  journal={Journal of virological methods},
  year={1993},
  volume={42 2-3},
  pages={181-91}
}
Procedures were developed for the screening and isolation of RNA viruses that vary from the consensus population by a single point mutation and are present in low abundance. We tested these procedures using a mixture of the vaccine donor line cold-adapted (ca) B/Ann Arbor/1/66 and its wild type (wt) progenitor at a ratio of 1,000:1. A 13-mer… CONTINUE READING