A probable aculeacin A acylase from the Ralstonia solanacearum GMI1000 is N-acyl-homoserine lactone acylase with quorum-quenching activity

@inproceedings{Chen2008APA,
  title={A probable aculeacin A acylase from the Ralstonia solanacearum GMI1000 is N-acyl-homoserine lactone acylase with quorum-quenching activity},
  author={C Y Chen and Chii-Jaan Chen and C. F. -H. Liao and C Y Lee},
  booktitle={BMC Microbiology},
  year={2008}
}
The infection and virulence functions of diverse plant and animal pathogens that possess quorum sensing systems are regulated by N-acylhomoserine lactones (AHLs) acting as signal molecules. AHL-acylase is a quorum quenching enzyme and degrades AHLs by removing the fatty acid side chain from the homoserine lactone ring of AHLs. This blocks AHL accumulation and pathogenic phenotypes in quorum sensing bacteria. An aac gene of undemonstrated function from Ralstonia solanacearum GMI1000 was cloned… CONTINUE READING

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