A probability model for the meiosis I non-disjunction fraction in numerical chromosomal anomalies.

@article{Franco2003APM,
  title={A probability model for the meiosis I non-disjunction fraction in numerical chromosomal anomalies.},
  author={Glaura C. Franco and Paulo S{\'e}rgio Lucio and Fl{\'a}via C Parra and Sergio Danilo Juno Pena},
  journal={Statistics in medicine},
  year={2003},
  volume={22 12},
  pages={2015-24}
}
Numerical chromosome abnormalities (aneuploidies) are among the most common known causes of mental retardation and the leading cause of pregnancy loss in humans. They primarily arise by the process of meiotic non-disjunction. We still know very little about the contribution of genetic and environmental causes for non-disjunction in humans. In order to increase our understanding of the epidemiology of human trisomies, it is necessary to establish the proportion of cases occurring in the first or… CONTINUE READING

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