A probabilistic framework for the reference dose (probabilistic RfD).

  title={A probabilistic framework for the reference dose (probabilistic RfD).},
  author={Jeffrey C Swartout and Paul S. Price and Michael L. Dourson and Heather L Carlson-Lynch and Russell E Keenan},
  journal={Risk analysis : an official publication of the Society for Risk Analysis},
  volume={18 3},
Determining the probabilistic limits for the uncertainty factors used in the derivation of the Reference Dose (RfD) is an important step toward the goal of characterizing the risk of noncarcinogenic effects from exposure to environmental pollutants. If uncertainty factors are seen, individually, as "upper bounds" on the dose-scaling factor for sources of uncertainty, then determining comparable upper bounds for combinations of uncertainty factors can be accomplished by treating uncertainty… CONTINUE READING