A probabilistic approach for deriving acceptable human intake limits and human health risks from toxicological studies: general framework.

@article{Slob1998APA,
  title={A probabilistic approach for deriving acceptable human intake limits and human health risks from toxicological studies: general framework.},
  author={Wout Slob and Moniek N Pieters},
  journal={Risk analysis : an official publication of the Society for Risk Analysis},
  year={1998},
  volume={18 6},
  pages={787-98}
}
The use of uncertainty factors in the standard method for deriving acceptable intake or exposure limits for humans, such as the Reference Dose (RfD), may be viewed as a conservative method of taking various uncertainties into account. As an obvious alternative, the use of uncertainty distributions instead of uncertainty factors is gaining attention. This paper presents a comprehensive discussion of a general framework that quantifies both the uncertainties in the no-adverse-effect level in the… CONTINUE READING

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