A pro-inflammatory role for Th22 cells in Helicobacter pylori-associated gastritis

@article{Zhuang2014APR,
  title={A pro-inflammatory role for Th22 cells in Helicobacter pylori-associated gastritis},
  author={Y. Zhuang and P. Cheng and Xiao-fei Liu and Liusheng Peng and Bo-sheng Li and T. Wang and N. Chen and Wen-hua Li and Yun Shi and Weisan Chen and K. Pang and M. Zeng and X. Mao and Shi-ming Yang and Hong Guo and G. Guo and T. Liu and Qian-fei Zuo and H. Yang and Liu-yang Yang and Fang-yuan Mao and Yi-Pin Lv and Q. Zou},
  journal={Gut},
  year={2014},
  volume={64},
  pages={1368 - 1378}
}
Objective Helper T (Th) cell responses are critical for the pathogenesis of Helicobacter pylori-induced gastritis. Th22 cells represent a newly discovered Th cell subset, but their relevance to H. pylori-induced gastritis is unknown. Design Flow cytometry, real-time PCR and ELISA analyses were performed to examine cell, protein and transcript levels in gastric samples from patients and mice infected with H. pylori. Gastric tissues from interleukin (IL)-22-deficient and wild-type (control) mice… Expand
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