A prion-like protein from chicken brain copurifies with an acetylcholine receptor-inducing activity.

@article{Harris1991APP,
  title={A prion-like protein from chicken brain copurifies with an acetylcholine receptor-inducing activity.},
  author={David A Harris and Douglas L. Falls and Franklyn A. Johnson and Gerald D. Fischbach},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1991},
  volume={88 17},
  pages={
          7664-8
        }
}
The mammalian prion protein (PrPC) is a cellular protein of unknown function, an altered isoform of which (PrPSc) is a component of the infectious particle (prion) thought to be responsible for spongiform encephalopathies in humans and animals. We report here the isolation of a cDNA that encodes a chicken protein that is homologous to PrPC. This chicken prion-like protein (ch-PrLP) is identical to the mouse PrP at 33% of its amino acid positions, including an uninterrupted stretch of 24… CONTINUE READING

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