A principle of natural self-organization

  title={A principle of natural self-organization},
  author={Manfred Eigen and Peter Schuster},
This paper is the first part of a trilogy, which comprises a detailed study of a special type of functional organization and demonstrates its relevance with respect to the origin and evolution of life. Self-replicative macromolecules, such as RNA or DNA in a suitable environment exhibit a behavior, which we may call Darwinian and which can be formally represented by the concept of the quasi-species. A quasi-species is defined as a given distribution of macromolecular species with closely… 
Abiotic self-replication.
In this Account, a variety of in vitro systems of increasing complexity are examined, from simple chemical replicators up to complex systems based on in vitro transcription and translation, providing an interesting window onto the molecular origins of life.
The hypercycle theory is reviewed, focusing on several theoretical approaches to the dynamics of these systems, from mean field models to spatially-extended hypercycles, for the study of reproducing and cooperating entities in the general context of ecology and landscape ecology.
A theory for the origin of a self-replicating chemical system. I: Natural selection of the autogen from short, random oligomers
  • D. White
  • Biology
    Journal of Molecular Evolution
  • 2005
If successful, such an experiment would be the first laboratory demonstration of the spontaneous emergence by natural selection of a genetic, self-replicating, and evolving molecular system, and might represent the first step in the prebiotic environment of true Darwinian evolution toward a living cell.
Artificial Chemistry and Molecular Darwinian Evolution of DNA/RNA-Like Systems I - Typogenetics and Chemostat
Two simplified models of Darwinian evolution at the molecular level are studied by applying the methods of artificial chemistry, including a metaphor of a chemical reactor (chemostat) and a simplified formal system Typogenetics, introduced by Hofstadter.
Origin and evolution of heredity-metabolism system
The C4N model calls for a stronger role of physico-chemistry in the understanding of the origin of life, and points out that functional differentiation of proteins closely correlates with the structure of the primitive tRNAs.
Package models and the information crisis of prebiotic evolution.
Onset of natural selection in populations of autocatalytic heteropolymers.
This work model the dynamics of 2-mers, i.e., sequential pairs of specific monomers within the heteropolymer population capable of template-assisted ligation based on Watson-Crick-like hybridization, and results in a limited subset of polymer sequences.
Molecular insights into evolution
A comprehensive model of evolution has been developed that allows as to follow optimization at full molecular resolution and initiated the development of new mathematical concepts which analyse evolution as a complex process viewed simultaneously in concentration space, sequence space, and shape space.
Modular evolution and increase of functional complexity in replicating RNA molecules.
It is quantitatively show that modular evolution has relevant advantages with respect to the direct evolution of large functional molecules, among them the allowance of higher mutation rates, the shortening of evolutionary times, and the very possibility of finding complex structures that could not be otherwise directly selected.


Selforganization of matter and the evolution of biological macromolecules
The causes and effect of cause and effect, and the prerequisites of Selforganization, are explained in more detail in the I.IA.
Low molecular weight deoxyribonucleic acid polymerase from calf thymus chromatin. II. Initiation and fidelity of homopolymer replication.
  • L. Chang
  • Biology, Chemistry
    The Journal of biological chemistry
  • 1973
Abstract Replication of polydeoxynucleotide templates catalyzed by the low molecular weight DNA polymerase from calf thymus chromatin proceeds only in the presence of a complementary initiator,
On the Tendency of Species to form Varieties; and on the Perpetuation of Varieties and Species by Natural Means of Selection
1. Lyell and Hooker’s own letter of introduction explaining the extraordinary circumstances; 2. An excerpt from Darwin’s unpublished draft, part of a chapter titled, “On the Variation of Organic
Recognition mechanisms of DNA-specific enzymes.
  • T. Jovin
  • Biology, Chemistry
    Annual review of biochemistry
  • 1976
The present study highlights the importance of knowing the carrier and removal status of canine coronavirus, as a source of infection for other animals, not necessarily belonging to the same breeds.