A principal component analysis of postinjury viscoelastic assays: clotting factor depletion versus fibrinolysis.

@article{Chin2014APC,
  title={A principal component analysis of postinjury viscoelastic assays: clotting factor depletion versus fibrinolysis.},
  author={Theresa L Chin and Ernest Eugene Moore and Hunter B Moore and Eduardo Lopez Gonzalez and Michael P. Chapman and John R Stringham and Christopher R Ramos and Anirban Banerjee and Angela Sauaia},
  journal={Surgery},
  year={2014},
  volume={156 3},
  pages={570-7}
}
INTRODUCTION The mechanisms driving trauma-induced coagulopathy (TIC) remain to be defined, and its therapy demands an orchestrated replacement of specific blood products. Thrombelastography (TEG) is a tool to guide the TIC multicomponent therapy. Principal component analysis (PCA) is a statistical approach that identifies variable clusters; thus, we hypothesize that PCA can identify specific combinations of TEG-generated values that reflect TIC mechanisms. METHODS Adult trauma patients… CONTINUE READING