A primordial RNA modification enzyme: the case of tRNA (m1A) methyltransferase.

@article{Roovers2004APR,
  title={A primordial RNA modification enzyme: the case of tRNA (m1A) methyltransferase.},
  author={Martine Roovers and Johan Wouters and Janusz M. Bujnicki and Catherine Tricot and Victor Stalon and Henri Grosjean and Louis Droogmans},
  journal={Nucleic acids research},
  year={2004},
  volume={32 2},
  pages={465-76}
}
The modified nucleoside 1-methyladenosine (m(1)A) is found in the T-loop of many tRNAs from organisms belonging to the three domains of life (Eukaryota, Bacteria, Archaea). In the T-loop of eukaryotic and bacterial tRNAs, m(1)A is present at position 58, whereas in archaeal tRNAs it is present at position(s) 58 and/or 57, m(1)A57 being the obligatory intermediate in the biosynthesis of 1-methylinosine (m(1)I57). In yeast, the formation of m(1)A58 is catalysed by the essential tRNA (m(1)A58… CONTINUE READING