A primitive T cell-independent mechanism of intestinal mucosal IgA responses to commensal bacteria.

@article{Macpherson2000APT,
  title={A primitive T cell-independent mechanism of intestinal mucosal IgA responses to commensal bacteria.},
  author={Andrew J Macpherson and Dominique Gatto and Erica J. Sainsbury and Gregory R. Harriman and Hans Hengartner and Rolf Martin Zinkernagel},
  journal={Science},
  year={2000},
  volume={288 5474},
  pages={2222-6}
}
The immunoglobulin A (IgA) is produced to defend mucosal surfaces from environmental organisms, but host defenses against the very heavy load of intestinal commensal microorganisms are poorly understood. The IgA against intestinal commensal bacterial antigens was analyzed; it was not simply "natural antibody" but was specifically induced and responded to antigenic changes within an established gut flora. In contrast to IgA responses against exotoxins, a significant proportion of this specific… CONTINUE READING
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