A primer of NAADP-mediated Ca(2+) signalling: From sea urchin eggs to mammalian cells.

@article{Galione2015APO,
  title={A primer of NAADP-mediated Ca(2+) signalling: From sea urchin eggs to mammalian cells.},
  author={Antony Galione},
  journal={Cell calcium},
  year={2015},
  volume={58 1},
  pages={27-47}
}
Since the discovery of the Ca(2+) mobilizing effects of the pyridine nucleotide metabolite, nicotinic acid adenine dinucleotide phosphate (NAADP), this molecule has been demonstrated to function as a Ca(2+) mobilizing intracellular messenger in a wide range of cell types. In this review, I will briefly summarize the distinct principles behind NAADP-mediated Ca(2+) signalling before going on to outline the role of this messenger in the physiology of specific cell types. Central to the discussion… CONTINUE READING

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